Aleksandrova D. Determination of some drugs on the influence of their anions on the sensibilized luminescence of europium (III) and terbium (III).

The thesis is devoted to search of new analytical forms based on europium (III) and terbium (III) complexes with hydroxyquinoline carboxylic acid fluoroamides derivatives and tetracyclines for the determination of some drugs applied in the form of salts of organic acids and bases. The cations of these salts do not interact with Ln(ІІІ), but the anions enhance or decrease the luminescence of Ln(ІІІ) complexes with organic ligands-sensitizers. Relationships of the luminescent characteristics of europium (III) and terbium (III) complexes of hydroxyquinoline carboxylic acid amide derivatives with the structure of ligands has been established by means of 2D-QSРR models, which were constructed on the simplex descriptors weighed by informational potentials of the atoms. The received models indicate priority influence of electronic polarization of the ligands and their topology on the quantum yield of luminescence and the lifetime of the excited state of lanthanide ions. It has been established, that addition of some organic and inorganic anions in Eu(III) - L system with the components ratio Eu(III):L=1:1 and рН 7.5 resulted in the formation of ternary complexes and in the increasing luminescence intensity of europium (III) ions. It has been established, that the luminescence of Tb(III) - L16 complex decreases at presence of phosphate-ions. It has been shown that ternary complexes can be used as new analytical forms for determination of some drugs. High-sensitivity, simple and express methods of determination of some drugs are developed on the basis of the studied complexes. Keywords: ternary complexes, terbium, europium, sensibilized luminescence, analysis of drugs.