Lytvynenko O. Indices of Lipid and Bile Acid Metabolism in Experimental Drug-induced Hepatitis and its Correction.

The dissertation is devoted to the studying of lipid and bile acids metabolism in conditions of modelling the drug-induced hepatitis in rats and mice and making a comparative estimation of corrective efficiency of liposomal form of biologically active addition FLP-MD on the basis of milk phospholipids and drug "Essentiale-Forte" on the basis of soy phospholipids. It was found that the modelling of drug-induced hepatitis in laboratory animals is accomponied by the development of typical clinical, pathological-anatomical and hystomorphological signs, hyperfermentation of hepatospecific enzymes, lipid metabolism disorder, decrease of synthetic, conjugative, eliminative functions of liver, development of intrahepatic cholestasia, activation of free-radical processes - increase content of products of the peroxidal oxidation of lipids and decrease in activity of antioxidant enzymes, protection including glutation system. It was proved the reparative, antiinflammatove, antiatherogenic, antioxidative, choloretic and cholagogic effects of biologically active addition FLP-MD, which are better expressed than during the us age of drug "Essentiale-Forte".