Anisimov V. Energetics mechanisms interaction of B vitamins as the factor of realization their functions

In the thesis co-operation of some B vitamins in realization of their functions is probed. It is shown that efficiency of transformation of vitamins of В1, В2 and РР in coenzyme forms maximally realized at a certain dose and correlations between them. Connection of these vitamins with other vitamins of group B (В3, В6) and lipoic acid allows considerably to promote their ability to transform in proper coenzymes. Efficiency of such action of vitamin composition (VC) grows on the measure of multiplying the amount of compounds for them, but for 5- and 6-component already achieves a border. It is set that both monovitamin preparations and compositions from them activate a pyruvate dehydrogenase complex (PDC) in the probed organs of rats. After the ability to cause the increase of activity of PDC polyvitamin compositions, and especially 4- and 5-component, in a few one time exceed such at monovitamins. Vitamins of group B and their compositions are able to stimulate formation of all factions of macroergic phosphates (nucleotid and non-nucleotid) in an organism only to the set border. Increase of amount of vitamins, and their doses results in the satiation of effect, and then - to his diminishing. Introduction the animals of vitamin preparations causes growth in their organs of common ATPase activity, thus a maximal effect was owned by 6-component VC. On the selected and cleared preparations of Na+, К+-АТPase from the organs of rats it is shown, that their common and specific activity is substantially (in once or twice) higher for animals which 6-component VC was preliminary entered.