Kundieva A. The effects of methyl tertbutyl ether on the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and several other genes in the organism.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0410U006465

Thesis Registration Form

0410U006465.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

13-12-2010

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

Object: PFKFB, SNARK and circadian genes. Aim: to investigate the effects of methyl tertbutyl ether on the expression of mRNA of PFKFB and circadian genes. Methods: biochemical and molecular biology. It was found that the expression of PFKFB, SNARK and curcadian genes mRNA and alternative splicing of its pre-mRNA change in different ways under the influence of metyl tertbutyl ether in rat liver, lung and heart. New alternative splice variants of PFKFB-4 and PFKFB-2 were dicovered which are induced under the influence of metyl tertbutyl ether. Scope: Organizations of medical and biological profile.

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Files

Disser.doc

aref.doc

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