Bekus I. The violation of lipid metabolism and its correction in rats with acute ethanol intoxication combined with a prolonged action of cadmium and lead salts.

The object - biochemical aspects of pathogenesis of acute ethanol poisoning in rats combined with 30-day introduction of cadmium chloride and lead acetate in subtoxic doses. The aim is to find out the features of lipid metabolism in the blood plasma and liver of rats with acute ethanol poisoning combined with a prolonged action of cadmium chloride and lead acetate in subtoxic doses, to explore the possibility of correction of these violations by the help of sodium alginate and carnitine. Methods - biochemical (spectrophotometric, colorimetric, spectroflyuorymetric), histological, statistics (the method of variation statistics using the Student t-criterion). Novelty - acute ethanol poisoning combined with a prolonged action of cadmium chloride and lead acetate in subtoxic doses causes a substantial violation of some indices of lipid metabolism (increasing of total lipids concentration due to triacylglycerols, decreasing of phospholipids concentrations, increasing of total cholesterol concentration, changing the ratio of its forms as a result of the predominance of free cholesterol, increasing of atherogenic ratio due to increasing of LDl-cholesterol and decreasing of HDL-cholesterol ) in the liver and blood plasma of rats, and, also activation of lipid peroxidation processes was found in this work for the first time. High efficiency correction of violations of lipids metabolism in rats, caused by acute ethanol poisoning combined with a prolonged action of cadmium chloride and lead acetate through the usage of carnitine and sodium alginate, which revealed normalization of lipid metabolism and inhibition of lipid peroxidation was determined.