Zdioruk M. "Molecular mechanisms of leucocytes aggregation ability under the type 1 diabetes"

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0411U004768

Thesis Registration Form

0411U004768.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

21-09-2011

Specialized Academic Board

Д 76.051.05

Yuriy Fedkovych Chernivtsi National University

Essay

The dissertation is devoted to the study of molecular mechanisms influencing the formation of an aggregation ability of leucocytes in cases of type 1 diabetes mellitus. It is proved that the aggregation ability of the cells studied, differs in healthy and pathological donors. It is shown that the phosphatidylinositol-3 -kinase enzyme takes part in the formation of the aggregation ability of mononuclear and polymorphonuclear leucocytes. Alteration in the interchange of p85 regulatory subunit of PI-3 -kinase content in the membrane and cytosolic fractions of leucocytes in cases of type 1 diabetes mellitus arises. These changes are correlated with changes of the aggregation activity of these cells.

Read more

Files

aref.doc

dis.doc

dis.doc

Similar theses

0524U000046

Oksana V. Melnyk

Peculiarities of free-radical, immune, Ca2+- and NO-dependent regulatory systems of cells and their relationship with the microbiome under conditions of development of male infertility and concomitant autoimmune pathology

0422U100167

Lylyk Mariia Petrivna

Protective action of alpha ketoglutarate in Drosophila melanogaster for exposure to xenobiotics

0422U100159

Semaniuk Uliana Vasylivna

Regulation of physiological and biochemical traits of Drosophila melanogaster by diet and insulin-like peptides

0422U100023

Kotliar Iryna Petrivna

Biochemical mechanisms of anti-inflammatory action of pyrrole derivatives in ulcerative colitis

0521U102076

Danylovych Hanna Victorivna

Biosynthesis and regulatory role of nitric oxide in smooth muscle mitochondria