Romelashvili O. Creating a new non-narcotic analgesic fenitison and development of suppository on its basis.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0411U006258

Thesis Registration Form

0411U006258.pdf

Applicant for

Specialization

  • 15.00.03 - Стандартизація та організація виробництва лікарських засобів

07-10-2011

Specialized Academic Board

Д 64.605.01

National University of Pharmacy

Essay

A combinatory library of new nicotinic and isonicotinic acid derivatives is planned and synthesized. As a result of biological studies of obtained relations a low-toxic substance-leader with expressed pharmacological activity which is a perspective non-steroidal non-narcotic analgesic is identified. The technological process of production of new is developed BAR under the conditional name - fenitizon. On the basis of the results of biological, physical, physicochemical, pharmaceutical technological, biopharmaceutical, rheological studies an appropriate composition and rational technology of antifebrile and anaesthetic medication with fenitizon in the form of rectal suppository are developed. Production technologies of fenitizon and the preparation on its basis are tested in the settings of proper domestic manufacturing facilities and the projects of technological regulations are developed

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Files

РОМЕЛАШВИЛИ Е.С._дисс.doc

Ромелашвили Е.С._Автореферат.doc

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