Berdyshev A. The effects of N-stearoylethanolamine on some biochemical processes under the immediate hypersensitivity, delayed-type hypersensitivity and nonspecific inflammation

Object - biochemical processes in allergic reactions and non-specific types of inflammation. Aim - the study the influence of N-stearoylethanolamine on biochemical processes in mammals during the development of immediate hypersensitivity reaction, delayed-type hypersensitivity and non-specific inflammation. Methods: the experimental animal models (anaphylactic shock in guinea pigs, contact hypersensitivity to 2,4-dinitrochlorobenzene in mice, non-specific inflammation after application of a thermal skin burn (stage III) in rats), ELISA, biochemical, fluorimetric, spectrophotometric, statistical. N-stearoylethanolamine caused the normalization of histamine content, of the constitutive and inducible NO-synthase, catalase, glutathione peroxidase, superoxide dismutase activity and the free amino acids content. N-stearoylethanolamine also inhibits the production of proinflammatory cytokines (TNFa, IL1, IL6) and TBA-reactive substance, which lies in the the basis of its antiallergic and anti-inflammatory action. These results extend the understanding of the biochemical mechanisms of action of saturated N-acylethanolamines and can be used to create a pharmacological preparations for correction and treatment of various pathologies including allergy and burns. Scope - organizations of medical and biological profile.