Vlasenko G. Sodium dodecylsulphate and Brij 35 micellar solutions as an alternative to 1-octanol-water system for investigation of distribution of biological activ substanses

The object of investigation: the partition of organic substances in 1-octanol-water two-phase system and water - surfactant micellar pseudophase system. Object of the research is to characterize the possibility of replacing the traditional hydrophobicity parameter logKo/w in the construction of the property-hydrophobicity correlation on the hydrophobicity parameter logKm/w, which characterize the distribution of substance between the water and the surfactant micellar pseudophase, and estimate the influence of heterogeneity of the experimental conditions of determining the hydrophobicity parameter logKo/w on the quality of the correlations. Methods of investigation and apparatus: spectrophotometry, HPLC, potentiometry, extraction, statistical treatment of the results of measurements, semi-empirical quantum chemistry program. Theoretical and practical results: the data sets of hydrophobic organic compounds filled with new experimental data of the distribution of multifunctional compounds in 1-octanol-water and water-micellar pseudophase systems. The results of direct experimental logKo/w determinations can be used to improve and test the schemes for hydrophobicity evaluations, to predict the solubility, bioavailability, and chromatographic retention of drugs and other organic compounds. Novelty: the requirements to the conditions of direct experimental determination of the hydrophobicity parameters have been specified. The influence of the micellar pseudophase on the spectral characteristics and protolytic properties of these substances was characterized. The possibility of using micellar solutions of surfactants for modeling biodistribution of organic compounds were further developed. For the first time it was shown that the replacement of hydrophobicity parameter logKo/w on logKm/w does not change the caracter of the biological activity-hydrophobicity dependencies among homologues. The degree of implementation: none. Sphere of application: the educational process, the research scientific work.