Balynska O. Characterization of oncogenic properties of gene encoding chitinase 3-like 1 protein (CHI3L1)

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0413U003220

Thesis Registration Form

0413U003220.pdf

Applicant for

Specialization

  • 03.00.03 - Молекулярна біологія

14-05-2013

Specialized Academic Board

Д 26.237.01

Institute of Molecular Biology and Genetics of NAS of Ukraine

Essay

Expression of CHI3L1 was found increased significantly in various tumors. It has been demonstrated that 293 cells stably producing CHI3L1 (293_CHI3L1) protein have the decreased doubling time and could anchorage-independent grow in soft agar. ERK1/2/MAPK pathway and AKT/PI3-kinase pathway are shown to be activated in the 293_CHI3L1 cells. 293_CHI3L1 cells stimulated the initiation of tumors after their xenograft transplantation into the adult rat brains. It was shown supression of malignant transformation in 293_CHI3L1 cells after decreasing level of CHI3L1 using specific siRNA_CHI3L1. Thus, overexpression of CHI3L1 causes malignant transformation of cells in vitro and initiates tumors in vivo suggested of CHI3L1 function in cancerogenesis.

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