Orishaka O. Distribution of thiamine and its phosphorylated forms at malignant process in uterus and ovaries

Object of study - thiamine metabolism in tumors of the reproductive system of women. The aim of study: to determine the distribution and characteristics of thiamine metabolism at the tissue and subcellular levels in tumor tissue and phenotypically unaltered and ovarian cancer women. Methods: differential centrifugation, salting, methods spectrophotometric, flyuorymetric, chromatographic, electrophoretic, statistical analysis. Theoretical and practical results, the novelty: the first explored and analyzed the features of the distribution of free and phosphorylated thiamine in the cells of benign and malignant tumors of the myometrium, endometrium and ovarian cancer patients women. The results are the differences regulation mechanisms thiamine pyrophosphokinase activity in tumors of the myometrium and in the surrounding tissue can be used to design drugs directed action. These research results in the thesis is to develop a rational justification for vitamin correction of hypo- and avitaminosis in patients with cancer.