Kuznetsova T. Antiradical activity of melatonin and glutathione on the results of quantum chemical and electrochemical studies

The antioxidant comparative activity modeling was performed on the basis of the interactions of melatonin hormone (MLT) and enzyme glutathione (GSH) with hydroxyl-radicals and superoxide-anion-radicals, using results of quantum chemical calculations and electrochemical measurements, that allowed to prove the microscopic mechanism of the anti-radical activity of these molecules by the offered scheme of the changes of inter-atomic distances between the "outer" atoms of MLT and GSH antioxidants upon the influence of *ОН and *ОО- radicals, and gave the opportunity to predict a set the most possible active centers of the discussed antioxidants that substantiate their antioxidant activity.