Voitenko V. The role of serotonin in the mechanisms of prediabetes in rats with chronic alcohol intoxication

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0414U000258

Thesis Registration Form

0414U000258.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

13-01-2014

Specialized Academic Board

Д 26.001.24

Taras Shevchenko National University of Kyiv

Essay

Functioning of serotonin biosynthesis pathway under conditions of chronic alcohol intoxication has been investigated. Carbohydrate and lipid metabolism in blood of rats serum under conditions of chronic alcohol intoxication has been investigated and analized. Changes of basic serum biochemical parameters in rats under conditions of chronic alcohol intoxication, compared with those in control, have been found. The disruption of the serotonin biosynthesis pathway under conditions of chronic alcohol intoxication has been shown. Basic indicators of the prediabetes occurrence on chronic alcohol intoxication have been investigated. Reducing of the glucose absorption rate, which may indicate the development of insulin resistance, a risk factor at type 2 diabetes, has been found.

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