Marunich R. Expression of key genes regulating glucose metabolism in transformed human cells and in rat tissues

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0414U003065

Thesis Registration Form

0414U003065.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

28-04-2014

Specialized Academic Board

Д 26.001.24

Taras Shevchenko National University of Kyiv

Essay

The thesis deals with solution of the actual scientific problem of the role of signaling enzyme ERN1 in regulation of expression of key glucose metabolism genes in tumor cells, and influence on the rate of proliferation of transformed cells. The level of mRNA expression of hexokinase-2, PFKFB-4, PFKFB-3, PFKL, PFKP, LDHA and PFKM depends on the function of ERN1, the major signaling enzyme of endoplasmic reticulum stress. It was shown, that the level of mRNA expression of glucose-6-phosphate dehydrogenase does not change in glioma cells with suppressed function of the enzyme ERN1, while hypoxia significantly reduces the expression of this gene, but only in cells with suppressed function of the enzyme ERN1.

Read more

Files

aref.doc

dis.doc

dis.doc

Similar theses

0524U000046

Oksana V. Melnyk

Peculiarities of free-radical, immune, Ca2+- and NO-dependent regulatory systems of cells and their relationship with the microbiome under conditions of development of male infertility and concomitant autoimmune pathology

0422U100167

Lylyk Mariia Petrivna

Protective action of alpha ketoglutarate in Drosophila melanogaster for exposure to xenobiotics

0422U100159

Semaniuk Uliana Vasylivna

Regulation of physiological and biochemical traits of Drosophila melanogaster by diet and insulin-like peptides

0422U100023

Kotliar Iryna Petrivna

Biochemical mechanisms of anti-inflammatory action of pyrrole derivatives in ulcerative colitis

0521U102076

Danylovych Hanna Victorivna

Biosynthesis and regulatory role of nitric oxide in smooth muscle mitochondria