Babiy S. Changes of biochemistry markers of the functional state of the kidneys in the tumor growth models in treatment by Rhenium compounds and cisplatin

It was shown that development of the Guerin carcinoma and introduction of cisplatin led to the damage of the kidneys of rats that was confirmed by an increase of relative kidney weight, proteinuria, change of gamma-glutamyl transpeptidase and lactate dehydrogenase activity in the urea and tissue homogenates of the kidneys, by a decrease of relative reabsorption and glomerular filtration. Introduction of nanoliposomal forms of the rhenium cluster compounds led to normalization of above mentioned diagnostic indexes and to reduction of the toxic cisplatin influence that was confirmed by biochemical and morphological investigations. For the first time, the ability of cluster Rhenium compounds to reduce cisplatin-induced oxidative stress in the kidneys in the model of tumor growth has been demonstrated. These data demonstrate antiradical properties of cluster Rhenium compounds in kidney tissue. The attempt was made to explain the mechanism of nephroprotective activity of the Rhenium compounds with quadruple bond.