Andreyev A. Pathological anatomy of adrenal glands in perinatal hypoxia

The dissertation is devoted to study of pathological changes of the adrenal glands of fetuses and neonates in perinatal hypoxia. The research is carried out about pathological changes in the adrenal glands of fetuses and newborns in perinatal hypoxia with autopsy and experimental material using. It is revealed that non-lethal (i.e. bearable) acute or chronic perinatal hypoxia modeled in experimental animals leads to activation in varying degrees apoptosis and proliferation processes in fasciculate zone of the cortex and medulla what forms different combinations of hyperplasia, hypertrophy, polyploidy of these structural units, interstitial collagens accumulation. It is observed hypoplasia, morphofunctional load reduction in glomerular zone of the cortex, fetal cortex, reticular zone of definitive cortex. Perinatal hypoxia-asphyxia with fatal outcome (autopsy) produces morphological picture of adrenal insufficiency in form of numerous foci of cytolysis (massive apoptosis) in fasciculate zone of definitive cortex (where it has already formed) in fetal cortex and almost medulla desolation in most cases. Hormonal study of cord and maternal blood revealed that Apgar scores of 6 at 1 minute are critical, since adrenal glands activation changes to exhaustion signs.