Gadiliya O. Biochemical mechanisms of action of pyrrolidine derivatives of 2-carboxylic acid on the gastric mucosa cells of rats in the conditions of experimental ulcer

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0415U000650

Thesis Registration Form

0415U000650.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

04-03-2015

Specialized Academic Board

Д 26.001.24

Taras Shevchenko National University of Kyiv

Essay

The thesis is devoted to the discovering of the biochemical mechanisms of pyrrolidine derivatives of 2-carboxylic acid effects on the gastric mucosa in the condition of experimental ulcer. The experiments help to reveal that the studied compound has a pronounced antiulcer effect on experimental ulcer models induced by stress, ethanol and nonsteroidal anti-inflammatory drugs (indomethacin and aspirin). The evaluation of antiulcer action of sodium 2-(2-hydroxyphenoxy)acetyl)-L-prolinate showed that its antiulcer properties are associated with a decrease in the intensity of lipid peroxidation and inflammation, normalization of eicosanoids and increased synthesis of protective heat shock proteins (60 and 70) and prostaglandin E2.

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Files

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