Burmas N. The age features of oxidative processes in rats by conditions of the combined influence by the tuberculostatics and hexavalent chromium.

The object – is a toxic affection of white rats by isoniazid, rifampicin and hexavalent chromium. The aim of the dissertation was to clarifying the age features of oxidative processes by conditions of the combined influence by isoniazid, rifampicin and hexavalent chromium in rats and developed of effective methods of the correction by using of antioxidants and enterosorbents. The methods of research: biochemical (spectrophotometric, colorimetric, spectrofluorimetric), statistical (the method of variation statistics by using of Student's t-test). Novelty – it was first proposed the model of toxic affection of rats by hexavalent chromium in combination with tuberculostatics. It was complex researched of passing of free radical processes and values of antioxidant system and endogenous intoxication, biliary formation processes in the organism of animals of different age by conditions of the combined influence by hexavalent chromium and anti-TB drugs. It was shown for the first time, by the conditions of chrome-isoniazid- rifampin's toxicosis the antioxidant of thiotriasolin manifests pronounced antioxidant, hepatoprotective and membrane-stabilizing properties. It was evidenced, by the decrease of the content of products of lipid peroxidation, oxidative modification of proteins, decrease the degree of the permeability of an erythrocyte's membrane and the content of molecules average weight, normalization of the values of antioxidant system, the restoring of functional activity of hepatocytes and normalization of biliary formation processes of affected animals. It was proved, that the most effective sorbeks had normalized values of endogenous intoxication and the status of antioxidant system in the organism of affected animals, that gives ground to use it as an enterosorbent by the conditions of a chemical affection on the background of drug's hepatitis.