Fedyakova O. Features of T-2 toxins metabolism and its impact on animals with the application of sorbents and vitamins A and E

Object - T-2 toxicosis and their correction. The aim of the thesis was to clarify the impact of T-2 toxin on hematological, biochemical parameters, antioxidant status and processes of lipid peroxidation in rats and chickens, setting efficiency neutralization of T-2 toxin in vitro chelators, substantiating correction of opportunities, caused by the arrival of mycotoxin in the animal organism when used sorbent "Aeros" and antioxidants (vitamins A and E), determining residual amounts of T-2 and HT-2 toxins in the blood and organs of chickens. Methods: hematologic, biochemical (spectrophotometric, chromatographic), ELISA and statistics. Novelty - For the first time analyzed the biochemical mechanisms of action T-2 toxin in rat erythrocyte morphofunctional state, the activity of antioxidant enzymes and lipid peroxidation processes under conditions of a single intragastric administration of toxin dose of 0.67 mg / kg. Revealed inhibitory effect of T-2 toxin on antioxidant system and stimulating effect on the processes of lipid peroxidation. For the first time demonstrated the effectiveness of sorbent "Aeros" to neutralize T-2 toxin. For the first time revealed the impact of the adjustment of vitamins A and E on the antioxidant system of hens in conditions of T-2 toxicity caused by oral intake of T-2 toxin at a dose of 0.56 mg / kg body weight. For the first time the analysis of residual amounts of T-2 toxin and its metabolite content, HT-2 toxin in the blood and organs of chickens.