Krupko O. Role of presanaptic glutamate receptors in the modulation of neurotransmission’s processes.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0415U005413

Thesis Registration Form

0415U005413.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

28-05-2015

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

TObject: isolated nerve terminals (synaptosomes) from hippocamp and cortex of rat brain. Aim: to investigate the intracellular events occurring in rat brain cortical and hippocampal nerve terminals under the activation of presynaptic glutamate receptors. Methods: preparative biochemistry, radioisotope methods, fluorescence spectroscopy using and pH-sensitive and ROS-sensitive fluorescent dyes. It has been revealed that activation of presynaptic glutamate receptors causes facilitation of inhibitory neurotransmitter GABA through stimulation of synaptic vesicles exocytosis. It was shown , that release of synaptic vesicles upon activation of presynaptic glutamate receptors occurs in two steps. The intracellular mechanism of effect of glutamate receptors activation involves reactive oxygen species production.

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Files

Диссертация_Крупко.doc

автореферат диссертации_Крупко О. О.doc

титульний аркуш автореферата.doc

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