Oshmianska N. Structural and functional features of the pancreatic islets in relation to the development of fibrosis in patients with chronic pancreatitis.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0415U005793

Thesis Registration Form

0415U005793.pdf

Applicant for

Specialization

  • 14.03.02 - Патологічна анатомія

29-10-2015

Specialized Academic Board

Д 17.600.04

Zaporizhzhya State Medical University

Essay

The dissertation is dedicated to study of the cellular composition, ways of death and regeneration in the Langerhans islets during the development of chronic pancreatitis. A significant decrease in the area of Langerhans islets with the progression of the disease has been confirmed (r=0,34; p<0,05), which is implemented mainly through apoptosis. Said changes actively involved non-caspase proapoptotic nuclease Endonuclease G, while the caspase proapoptotic nuclease DNase I has been localized in the cytoplasm of acinar cells. The regeneration of the Langerhans islets in chronic pancreatitis also has been proved and occurs in several ways, including the involment of Ngn3-positive progenitor cells. Restructuring of islet apparatus begins in the early stages of chronic pancreatitis, and appears to reduce the relative amount of islet's b-cells, resulting in a significant increase in the ratio of a-cells to b-cells (p<0,05). Experimental studies help to show that obstructive chronic pancreatitis is characterized by activation of fibrosis and regeneration of islets, while the alcoholic - by the almost complete absence of active proliferation and regeneration of functional tissue.

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