Lupak M. Molecular mechanisms of Galega officinalis extract antidiabetic action.

The main purpose of work was to research biochemical effects of alkaloid-free Galega officinalis L. fraction on structural and functional state of rats' leucocytes and pancreatic cells under conditions of experimental diabetes mellitus. A method of alkaloid-free fraction from Galega officinalis stabilization by addition of biological surface active agent was developed, were found component composition of stabilized fraction. Pronounced hypoglycemic effects of stabilized alkaloid-free fraction from Galega officinalis and its cell protective effects on Langerhans islet cells of the pancreas system were shown. Stabilized fraction from Galega officinalis prevents the development of oxidative stress under experimental diabetes conditions. Was shown a depressive influence of Stabilized alkaloid-free fraction from Galega officinalis on leucocytes apoptosis. A corrective influence on the proliferation and differentiation of leucocytes' precursor cells, on actin polymerization process of these cells and on TNF-alpha content was also discovered in our studies of pathology.