Boiko L. Metabolic disorders in animals organisms at the condition of combined affecting of tetrachloromethane and carbophos and the ways of their correction

The thesis is related to the study of the peculiarities of oxidative processes in mammals under the conditions of separate and combined affecting of tetrachloromethane and carbophos, justified the application of antioxidants and enterosorbents. It was proved that the combined affecting of animals by tetrachloromethane and carbophos leads to significant activation of lipid and proteins peroxidation, violations of the functional state of the antioxidant system, deepening of the endogenous intoxication, changing in membrane permeability of hepatocytes and erythrocytes, cell energy disturbances processes and changing in hydrocarbon metabolism. Revealed the reduced activity of acetylcholinesterase after the administration of carbophos in the organisms that indicates the neurotoxic effect of this xenobiotic. It is shown that under the combined affecting of tetrachloromethane and carbophos the antioxidant mexydol shows pronounced antioxidant, antihypoxic and membrane-stabilizing properties. The administration of enterosgel leaded to the reduction of endogenous intoxication, which is in turn reduced the toxicity effects of carbophos and tetrachloromethane in the organisms. At this case it was inhibition of the oxidative processes, indicated by the reduction of TBA-active products and products of protein oxidative modification and partial restoration of antioxidant system activity and activity of key enzymes and bioenergy processes.