Skirak Z. Disorder of serum albumin connective function during toxic hepatitis.

It was determined the role of serum albumin connective tissue function disorder in pathogenesis of acute toxic hepatitis caused by alcohol, hydrazine hydrochloride and tetrachlormethane. It was ascertained that during acute toxic hepatitis simulation, inspite of its origin, connective function of serum albumin statistically authentically decreases. The disorders of liver toxic markers occur which increase from alcohol to tetrachlomethane damage. Under these circumstances connective function of serum albumin correlates positively with general albumin amount and albumin-globulin correlation, and negatively with cytolysis and cholestasis. The amount of correlations and their intensity increases from thesecond to seventh day after simulation and is proportional to hepatitis gravity. Usage of Glutargin to correct acute toxic liver damage of different etiology on the seventh day is accompanied with significant increasing of serum albumin connective function, inspite of liver toxity markers disorders. The effect of Glutargin is higher during acute toxic tetrachlormethane hepatitis.