Lisnianska N. The role of oxidative processes in the mechanisms of chronic enterocolitis development against the background of the experimental streptozotocin-induced diabetes.

The thesis deals with features of oxidative processes and with the clarification of their role in the mechanisms of chronic enterocolitis development against the background of the experimental streptozotocin-induced diabetes in rats. It has been established that under the condition of chronic enterocolitis against the background of streptozotocin-induced diabetes oxidative processes in the small intestine are activated and the activity of superoxide dismutase and catalase decreases as well, which is reflected in the blood of the animals under investigation. Chronic enterocolitis against streptozotocin-induced diabetes in rats is accompanied by a shift of the leukocyte formula to the left and the development of endogenous intoxication, the metabolic result of which is the enhancement of cellular degradation. The intensification of the processes of oxidative destruction is accompanied by changes in the enzymatic activity of energy supply indicators, which leads to destructive damage to the small intestine cells and an increase in the percentage of leukocytes with signs of early and late apoptosis. The factors that trigger apoptotic death in rats with chronic enterocolitis against streptozotocin-indeced diabetes include active forms of oxygen and tumor necrosis factor, but a stronger association with active forms of oxygen has been established. The resulting changes have been confirmed morphologically.