Tikhova Y. Biochemical indices of development of experimental osteoarthrosis of rats

Among the disorders of the locomotor system, an important place is occupied by degenerative-dystrophic diseases of the joints, the main of which is osteoarthritis. Among the mechanisms of formation of osteoarthritis today is the development of oxidative stress in cartilage tissue and the general inflammatory aspect of the pathogenesis of this disease, which can lead to a disruption of the metabolism of connective tissue, inflammatory and degenerative changes in the cartilage. Scientific research on the relationship between the development of osteoarthritis and the state of oxidative-antioxidant balance in cartilage tissue are limited and fragmentary. In particular, a complex glutathione system, an oxidation modification of proteins and lipids in MIA-induced osteoarthritis in rats has not been investigated. Often, osteoarthritis affects the joints of the brush, the first plyusnefalangovy joint of the foot, joints of the cervical and lumbar spine, knee and hip joints. However, the severity of the disturbance of the musculoskeletal system occupy the first place in the hip, knee and ankle joints, as well as the shoulder joint. Thus, osteoarthritis is a group of diseases of the joints that manifest themselves as progressive cartilage tissue dystrophy followed by damage to the connective tissue and bone tissue, which leads to a gradual deterioration in the quality of life of the patients and their disability.