Khmil D. NO- and arginase-mediated mechanisms of nitrosative-oxidative stress and depolymerization of the skin connective tissue biopolimers under conditions of excessive intake of sodium nitrate

This dissertation is focused on the theoretical generalization and solving the tasks aimed at determining the role of NO- and arginase-mediated pathways in the biochemical mechanisms of nitrosative-oxidative stress in the skin of rats and depolymerization of the connective tissue biopolimers under conditions of excessive intake of sodium nitrate. For the first time, it has been found out that the administration of sodium nitrate for 30 days results in dysregulatory changes in the functioning of biochemical mechanisms responsible for autoregulation of nitric oxide concentration in skin tissues It has been shown that the co-administration of L-arginine and NF-?B activation inhibitors (PDTC, corvitin) is a more effective means of preventing oxidative-nitrosative stress in the skin and its disorganization in the conditions of excessive sodium nitrate intake compared with their separate administration.