Herasymenko V. Evolution hemorahiynoho Schonlein-Henoch vasculitis that began in childhood and adulthood, morphological and pathogenetic comparisons

The target of research is the clinical and morphological evolution and pathogenesis of Schönlein–Henoch purpura (vasculitis) (SHP), which onset in childhood and adulthood; the goal is to improve the quality of the diagnostics, to establish new links in pathogenesis and to distinguish prognostic criteria of the SHP course, which onset in childhood and adulthood, methods – clinical, X-ray, ultrasound, electrophysiological, biochemical, immunobiochemical, immunoenzyme, immunoblotting, physico-chemical, morphological, statistical; novelty and results – the peculiarities of the clinical and laboratory course of the skin, joints, kidneys and heart lesions in patients with the onset of SHP in childhood and adulthood are determined for the first time, the dependence of evolutionary changes due to the shifts of the immune system parameters is proved, the relationships of visceritis with skin and articular syndromes are revealed, violations of endothelial function of blood vessels and vascular-rheological properties of blood and the correlation of their parameters depending on the age debut of the disease are revealed for the first time, the importance of endothelium-dependent vasodilators and endothelium-dependent vasoconstrictors disbalance, surface-active, viscous, elastic and relaxation properties of serum in the pathogenesis of SPH in the context of the onset process age is proved; the criteria, allowing to predict the course of SPH in patients with different age disease debut are substantiated; it is implemented into the medical process of the Clinical Facility “Primary Health Care Center No. 1 in Kramatorsk”, Municipal Medical Facility “Children's Territorial Medical Association of Kramatorsk”, the Rheumatological Departments of the Research Institute of the Disabled Rehabilitation (educational and scientific medical complex) at the Vinnytsia National Medical University named after M.I.Pirogov, Medical Facility “Dniprovska City Clinical Hospital No. 11”, Lviv Regional Clinical Hospital, Center for Rheumatology at the “Theophiania” Clinical Hospital of the State General Affairs Department (Kyiv), as well as into the pedagogical process of the Donetsk National Medical University; the sphere of application – the medical-diagnostic process of rheumatological, therapeutic, pediatric departments, the educational process of therapeutic and pediatric profiles departments at medical educational institutions.