Klys Y. State of the hemostasis system in the inflammatory and oncological processes of ENT organs.

During the implementation of the dissertation a comprehensive study was carried out on the content and activity of the components of the hemostasis system in patients with chronic tonsillitis, benign, precancerous and malignant neoplasms of ENT organs. Significant changes were observed in indices of fibrinolytic, coagulation system of the hemostasis and components of the plasma inhibitory potential. The obtained results broaden the understanding of the role of components of the hemostasis system and the changes in their content and activity in inflammatory and oncological processes of ENT organs. The main cause of lethality in malignant neoplasms of ENT organs is local relapses and metastases to the lymph nodes of the neck, with high mortality rate among patients already in the first year after diagnosis. The use of standard criteria based on the clinical and morphological characteristics of the tumor process to evaluate the prognosis of the course of the disease is not informative. The data obtained in the work allowed to create a prognostic index that took into account the abandonment of the control of the preoperative indexes of fibrinogen content, α2-macroglobulin and the level of thrombin-like activity. The proposed index allows to predict the occurrence of relapse or metastases in patients with stage III laryngeal cancer, which is extremely necessary for patients with such tumors due to the high frequency of their development and the main cause of mortality in patients.