Rutska A. Gender- and age-specific characteristics of oxidative processes in rats exposed to tobacco smoke in a setting of monosodium glutamate use

The thesis is devoted to the study of the peculiarities of prooxidant-antioxidant balance, energy supply oxidation and the implementation of cell death in rats of different age and sex exposed to tobacco smoke, monosodium glutamate and their combined use. This is the first comparative study of specific features of oxidation, antioxidant protection and peculiarities of implementation of programmed cell death in animals in isolated effect of tobacco smoke and in combined effect of the latter with monosodium glutamate depending on gender and age of animals. Passive smoking in a setting of monosodium glutamate use in mature animals was found to intensify nitroxydergic processes (this phenomenon was more pronounced in females); immature animals were found to have attenuation of nitroxydergic processes in isolated effect of tobacco smoke.