Ilnytska K. The activity of nitroso-oxidative processes in the digestive system organs under conditions of the low instensity X-ray irradiation, stress, cyclooxygenase blockage effect and its correction with vitamin E and 1.4-naphtoquinone derivative.

The aim of research was to investigate the nitroso-oxidative processes changes in mucous membranes of the stomach, small and large intestine under the conditions of stress and cyclooxygenase blockage effect on the background of the low intensity X-ray irradiation and correction with vitamin E and 1.4-naphtoquinone derivative. Experimental studies were conducted on white nonlinear male rats 180-230 g (n=138). We revealed antioxidant effect of 1.4-naphtoquinone, accompanied by the changes of lipid peroxidation processes, NO-synthase/arginase system, myeloperoxidase activity in digestive organs mucous membranes both under the conditions X-ray irradiation and COX blockage or influence of stress on the background of simultaneous effect of 1.4-naphtoquinone and X-ray irradiation. The exposure to water-immersion stress on the background of the combined effect of аlfa-tocopherol and low intensity X-ray irradiation did not exert any significant influence on the changes of activity of iNOS, cNOS, arginase, nitrite-anion content and sum of nitrates and nitrites, TBA-active products and SOD activity; iNOS activity and TBA-active products content were significantly lower, compared to indices obtained under the independent effect of water-immersion stress. We established the changes of L-arginine concentration, content of nitrite-anion and hydrogen chloride in blood plasma both in stress and under conditions of COX blockage on the background of low intensity X-ray irradiation as well as under the influence of stress/COX blockage at administration of alfa-tocopherol/1.4-naphtoquinone derivative and X-ray irradiation