Nechytailo L. Influence of cadmium and nitrate compounds on micro-and macro-elemental composition of the organism of experimental animals.

The dissertation is devoted to the study of the separate and combined effects of cadmium chloride and sodium nitrate on the level of macroelements (Calcium and Magnesium) and microelements (Kuprum and Zinc) in organs and tissues, activity of metalloenzymes (alkaline and acid phosphatase, Na+, K+ -Mg2+ -dependent ATP-phase, lactate dehydrogenase, ceruloplasmin, catalase) and to determine the correlation between the content of metals and the activity of enzymes in the organism of experimental animals. It was established that excessive intake of cadmium and nitrate salts leads to the development of dysmicroelementosis, which is accompanied by a disruption of the homeostasis of essential macro and microelements, changes in the activity of metalloenzymes, which play an important role in the regulation of calcium-phosphorus metabolism, energy supply of cells and antioxidant defense. Evaluating the level of such toxicants in the objects of the environment and understanding the mechanisms of their influence on living organisms is crucial for the prevention of environmental pathologies