AL-BAHADLY A. Research of mechanisms of thermoregulation and long-term life in experiment.

The dissertation is devoted to research of mechanisms of thermoregulation, their role in ageing processes, interrelation with indicators of pro- and antioxidant systems and the hormonal background of experimental animals. It shown that overeating from birth to 21 days postnatal ontogenesis was accompanied by an increase in body weight by 32 % compared with the control group of animals. Determination of changes in the body weight of animals in ontogenesis has shown that even with abstinence in standard conditions,as well as groups of control animals, they retained predominance by weight of the body of control animals to almost 31 months of age. Increased mortality under the conditions of such animals at a temperature of 32 0С; an increase in the content of lipid hydro peroxides, an increase in the activity of NO-synthase in the liver, brain, heart, kidneys and a decrease in the activity of glutathione peroxidase; an increase in thyroxin content in the serum, a decrease in lifespan. The metabolic status, formed in animals with overeating at an early stage of ontogenesis, persisted throughout the ontogenesis. The relationship between the survival rate of Grehan, the content of thyroxin in serum and body temperature on the calorie-restricted diet and the model of overeating at the early stage of ontogenesis has been established. The relationship between increasing the content of lipoprotein hydro peroxides, NO-synthase activity, the decrease of glutathione peroxidase activity and change in the micro plasticity of endoplasmic network membranes in hepatocytes on the model of overeating in RPO was shown. It was found that in mitochondria of experimental hyperthyroid animals free-radical production was increased, expressed by a 50 % increase in lipid peroxide content in mitochondria. The high levels of thyroid hormone are associated with the growth of fatty hydrocarbons in liver microsomes (about 30 %), but it was less pronounced than hepatocellular mitochondria. It is shown that an increase in body temperature with experimental hyperthyroidism is associated with the action of thyroxine on dissociation of oxidative phosphorylation in mitochondria. The lowering of the body temperature of experimental animals caused intoxication with high doses of copper sulfate without affecting the serum thyroxin content. Consequently, mechanisms of short-term change in body temperature during overeating, calorie-restricted diet and intoxication of the body with copper ions were different.