Bokotko R. Regenerative Processes in the Thyroid Gland of Animals for Hypothyroidism and Their Stimulation by Mesenchymal Stem Cells

The dissertation is devoted to the study of the mechanism of influence of mesenchymal stem cells mesenchymal stem cells on the course of reparative processes in the thyroid gland of white rats, cats and dogs. The influence of mesenchymal stem cells on restoration processes in the parenchyma of the thyroid gland of animals has been proved. The effect of allogeneic mesenchymal stem cells on reparative processes in rats with their therapeutic purpose after experimental hypothyroidism, as well as the effect of allogeneic mesenchymal stem cells on the course of reparative processes in cats and dogs has been studied. The morphological composition of blood, hormonal state after application of cellular material for correction of reparative processes in the thyroid gland has been studied. For the first time in the comparative aspect between different groups of experimental animals and different methods of administration of allogenic mesenchymal stem cells, the nature of the manifestation of microstructural changes in the thyroid gland of animals for experimental hypothyroidism is presented. From the 20 to the 90 days, the regenerative processes gradually increased, and on the 90 day of observation, the microscopic structure of the thyroid gland was almost no different from the normal, although it had some peculiarities. Thus, the results of our histological studies show that, in experimental hypothyroidism, the use of mesenchymal stem cells s in any way significantly accelerates the restoration of the structure of the thyroid gland as compared with the traditional method of treatment.