Luhinich N. The state of antioxidant system and hydrogen sulfide metabolism in experimental diabetes mellitus and influence of melatonin

The study is devoted to the investigation the state of oxidant-antioxidant system, including glutathione antioxidant protection system, as well as the level of hydrogen sulfide and the activity of the enzymes for its synthesis in liver and blood of rats under the physiological norm and alloxan-induced diabetes and influence of exogenous melatonin. For the first time described comprehensive study of the antioxidant state, changes in the content of hydrogen sulfide and of the enzymes for its synthesis under normal conditions and experimental diabetes mellitus, have investigated the effect of melatonin on the detected disorders. It is shown that melatonin has a normalizing effect on the synthesis of hydrogen sulfide in the liver and blood of rats with diabetes. For the first time performed correlation analysis and proven the connection of indicators of the hydrogen sulfide metabolism and oxidative-antioxidant system of liver for alloxane-induced diabetes and melatonin administration. The data wich obtained in the work can be the theoretical basis for arguing the use of this drug as a means of pathogenetic correction of the functional ability to counteract oxidative stress in liver diseases.