Azyrkina I. Scientific and practical substantiation of the application of microbiological methods for determining antibiotic residues in poultry products

The dissertation theoretically and experimentally substantiates the use of microbiological methods for determining the residual content of antibiotics in poultry products. For the first time in Ukraine, screening microbiological methods for determining the residual content of antibiotics of the group: tetracyclines, β-lactams, macrolides, aminoglycosides, quinolones, bacitracins in poultry products have been developed. The sensitivity of the developed microbiological methods for determining the residual content of antibiotics of 6 groups for poultry meat, fat, liver, kidneys, eggs, which meets ½ established by national legislation MDR, which fully satisfies the requirements for screening methods. The specificity and accuracy of the developed methods was 98%. The 100% efficiency of the developed microbiological methods for determination of residues of antibiotics of the group: tetracyclines, β-lactams, macrolides, aminoglycosides, quinolones, bacitracins was confirmed by comparison with the reference method LC-MS / MS. The practical value of the work lies in the introduction into laboratory practice of guidelines for determining the residual content of antibiotics in poultry products, which allowed to expand the list of antibiotics, the residual content of which can be determined, expand the network of laboratories capable of conducting these studies consumables used in the work.