Chetyrkin S. Role of the Cellular Retinol-Binding Protein on Interaction of Retinol with Nuclei

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0499U000408

Thesis Registration Form

0499U000408.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

22-02-1999

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

Cellular retinol-binding protein (CRBP), nuclei, chromatin, nuclear envelope of rat liver cells. Study of CRBP role in interaction of retinol with nuclei and nuclear structures. Methods - chromatography, UV and fluorescent spectroscopy, ultracentrifugation and radioisotope methods. CRBP from bovine liver and chicken stomach have been isolated and characterized. It has been shown significant decrease of vitamin A level in rat liver under chronic intake of 137Cs. It has been established that chronic intake of 137Cs leads to decrease of specific binding of retinol-CRBP complex by nuclei or nuclear components. The data obtained seem to be important for further study of molecular mechanisms of vitamin A action. Field of application - scientific institutions of medico-biologic type.

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