Shebbani M. Mechanisms of adaptation to copper sulfate of different ages

The dissertation is devoted to elucidation of metallothioneines role i n the mechanisms of adaptation to copper sulfate in animals of different ages. It was shown the role of metallothioneines in maintaining and intracellular dis tribution of metal ions in hepatocytes that made it possible to explain the rol e of metallothioneines in adaptation mechanisms. Age peculiarities of animals a daptation to prolonged impact of copper sulfate depended on the pattern of i ntracellular distribution of the toxicant. The effect of copper ions depended on functional status of biological systems and repeated consecutive injections of the low copper sulfate doses. The induction scheme of adaptation to copper s ulfate in animals was elaborated. It may be used in adaptation mechanisms and their ontogenetic changing investigation and in antitoxic drugs estimation as w ell.