Krysan K. Rearrangements of plasmid pATV 8 structure in transgenic mice.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0499U001255

Thesis Registration Form

0499U001255.pdf

Applicant for

Specialization

  • 03.00.03 - Молекулярна біологія

18-05-1999

Specialized Academic Board

Д 26.237.01

Institute of Molecular Biology and Genetics of NAS of Ukraine

Essay

Transgenic mice. To investigate the structural and functional interaction between transgene and host genome. Methods of investigation are molecular-biological and embryological methods. Theoretical and practical results - the model system has been constructed, the interaction between plasmid pATV 8 and mouse genome has been studied. Novelty- results concerning prognosing of exogenic DNA behaviour in geterologic cells were obtained, the parameters of the murine extrachromosomal transgene were investigated. Degree of introduction -recommendations for construction of transgenic animals. A branch of application - biotechnology.

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