Skomorovs'ka-Prokvolit O. Effect of fibrinogen/fibrin and their fragments on Glu-plasminogen properties

Human plasminogen.Study of the changes in Glu-plasminogen properties upon its interaction with fibrinogen/fibrin and their proteolytic fragments. Partially hydrolyzed fibrin induces conformational changes in intact plasminogen resulting in Glu-plasminogen transfer to Lys-plasminogen like state. Fibrinogen E-fragment induces the formation of the active center in Glu-plasminogen by conformational changes upon interaction. The formation of fibrin D-dimer complex with Glu-plasminogen is shown. It is shown that at the beginning stages of hydrolysis fibrin monomer the plasmin affinity to fibrin is increased. plasmin affinity to fibrin is in creased. The obtained data seem to be important for further study of molecular mechanism of fibrinolysis. Field of application - scientific institutions of medical and biological type.