Sumbayev V. The regulation of xanthine oxidase and xanthine dehydrogenase activity by ascorbic acid and functionaly relative compounds

3. Xanthine oxidase, rats, guinea pigs, people. To study the in vitro effects of antioxidants, corticosteroids, caffeine, histidine and folate on xanthine oxidase activity and the in vivo effects of some of them on uric acid formation. Methods: affinity precipitation, thin-layer chromatography, spectrophotometry. Established that antioxidants, corticosteroids, caffeine, histidine and folate are inhibit xanthine oxidase in vitro. In vivo the ascorbic acid and hydrocortisone are inhibit the uric acid formation. Also established the straight correla- tion between the activities of xanthine oxidase, glutathione antioxi- dant system and lipid peroxidation. Obtained data are important in studies of the xanthine oxidase activity and uric acid formation regulation. Field of application - scientific institutions for medical and biological studies.