Ladokhin O. Molecular biology aspects of protein-membrane interactions: thermodynamic and kinetic control of insertion

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0501U000413

Thesis Registration Form

0501U000413.pdf

Applicant for

Specialization

  • 03.00.03 - Молекулярна біологія

20-11-2001

Specialized Academic Board

Д 26.237.01

Institute of Molecular Biology and Genetics of NAS of Ukraine

Essay

First a structural and thermodynamic conception of post-translational insertion of proteins into membrane has been proposed and proved. The transition of a protein from the water soluble state to an interfacial intermediate is shown to be under the thermodynamic control, while the final stages of insertion are influenced by the kinetic control. The energetic consequences of membrane-induced secondary structure formation have been estimated. New approaches, which allow to use fluorescence spectroscopy to answer fundamental structural and thermodynamic questions of protein-membrane interactions have been developed.

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