M'yasoyedov V. The molecular mechanisms of synthetic surfactants biological action

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0502U000001

Thesis Registration Form

0502U000001.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

13-12-2001

Specialized Academic Board

Д 26.551.01

Essay

Wistar rats, white mice, detergent production factory workers. The new group synthetic surfactant (nitrogen-containing imidazolynes, phosphorus-containing detergents, neonoles) biological action establishment in the human and warm-blooded animal organism; diagnosis method grounding the harmful influence of synthetic detergents on the organism and elaboration of the given compound class hazard prognosis methods for the human. Investigation methods: Biochemical, enzymological, radioimmune, radioreceptore, histochemical, electromicroscopic, statistic. For the first time the biological action of a synthetic detergent new group in the warm-blooded organism was researched; the free-radical pathology diagnosis and the investigating substance biological action prognosis methods were grounded. The detergent-xenobiotics biological action mechanisms were shown to be realized via membranotoxic effects, free-radical process enhance, toxic and oxidizing stress development. Xenobiotic biotransformation and oxidoreduc tive system states, the state of neuroendocrine regulation and neurotransmittery processe were studied at the detergent influence conditions. The mathematical pattern of detergent bilogical effect prognosi was elaborated. The obtained data were used during the elaboration of state standarts of detergent contents in enviromental objects and during composing the treating-prophylaxy means at detergent production industry places. Area of application: medical biochemistry, public health service.

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