Donchenko L. Age-specific peculiarities of dysbolism development for patients with the support-moving apparatus trauma (diagnosis and prediction)

Investigation object: patients with the support-moving apparatus trauma and people without trauma. Investigation purpose is to reveal the age-specific peculiarities of metabolism processes changes at acute period of support-moving apparatus trauma for patients with uncomplicated and complicated flow of the post-traumatic period and on this base to develop the methods of the earlier diagnosis and prediction of development of infectious-inflammatory and degenerate-dystrophy complications. Investigation methods: biochemistry, statistics, mathematics. Theoretical and practical results, novelty of the investigation: It was obtained the new knowledge about the influence of electrolytes, carbohydrates, proteins, lipids and enzyme activity in serum blood of young and adult patients with uncomplicated and complicated flow of the post-traumatic period. It was shown that the metabolic processes of the acute trauma period correlate with peculiarities of further flow of the traumatic illness and depend on the patient age. The integral parameters of metabolic processes at the acute period of the trauma for patients with complicated and uncomplicated flow of the traumatic illness were established. It was firstly proved that the progressing of the degenerate-dystrophy processes for patients accompanies by the decrease of creatinine content and by the increase of the acid phosphatase in serum blood. The earlier diagnosis method of infectious- inflammatory complications, the diagnosis method of degenerate-dystrophy processes during the dynamics of the traumatic illness and the prognosis algorithm of the development of complications after the trauma for the young and the adult patients were developed. Degree of application: the obtained results were used in methodological recommendations of MHS of Ukraine. Area of application: biochemistry, health service.