Oliynyk S. Antioxidant defence at pathological conditions which are intermediate by the oxidatition stress

Objects - biochemical mechanisms of realization antioxidant protection in conditions of oxidizing stress at pathological statuses (daunorubicine and barbiturate intoxication, haematic hypoxia, different physical loadings, haemolitical anemia, dislipidemia and oncological diseases). Methods - biochemical, biophysical, physical-chemical, physiological, biological, pharmacological. Newness - finding out of biochemical mechanisms of antioxidant protection at pathological statuses which are realizing by oxidizing stress (daunorubicine and barbiturate intoxications, haematic hypoxia, physical and hypergravitation loadings, haemolitical anemia, dislipidemia and oncological diseases). Results - the opportunity of correction of the specified pathological statuses with the help of a line of perspective domestic preparations of a natural origin (poliphytol-1, splenosid), connections being derivative of organism inherent substances, derivative inherent, as an amber acid (sodium succinate, sufan, yakton) and butiric acid (ufibrat, claster Rhenium complexes with g-aminobutiric and isobutiric acids) is shown. The mechanisms of antioxidant protection realization of natural preparations and derivative substances inherent of organism are determined at development of oxidizing stress at daunorubicine and barbiturate intoxication, haematic hypoxia, hypergravitation and physical loading, haemolitical anemia, ischemical illness of heart and at oncological pathology. Branches - experimental medicine, clinical pharmacology, clinical cardiology, clinical toxicology, clinical oncology, hematology, sports medicine, military medicine, airspace medicine, veterinary medicine.