Ushakova G. The role of glycosaminoglycan-binding proteins in morphogenesis and plasticity of the brain

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0505U000375

Thesis Registration Form

0505U000375.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

08-06-2005

Specialized Academic Board

Д 64.051.17

Essay

Subject: The total level of heparansulfate- and hyaluronate-binding activity of proteins in brain. Aim: To investigate the role of macromolecule that specific bind the heparansulfate and hyaluronate during different stages of rat and human brain morphogenesis under normal conditions, and effect of hyperphenylalanunemia, 131I-inducable maternal hypothyroidism, low dose irradiation, somatogenic postoperative pain to rats was investigated. Materials and Methods: biochemical, immuno-, cytochemical, it was developed solid phase and histochemical carbohydrate analysis. Novelty: It was proposed the conception of morphogenic events (proliferation, migration, adhesion, synaprogenesis) depends of total level of heparansulfate- and hyaluronate-binding activity of extracellular/cytoskeleton brain protein. The new membrane-associated heparansulfate-binding proteins from newborn rat brain (19 и 28 кДа) and membrane hyaluronate-binding proteins from embryonic human brain (250 и 20 кДа) were purified. Field of implementation: laboratory and diagnostic biochemistry, biotechnology.

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