Skok M. Structure and functions of nicotinic acetylcholine receptors in B-lymphocytes

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0506U000416

Thesis Registration Form

0506U000416.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

03-07-2006

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

The object of investigation is nicotinic acetylcholine receptor (nAChR). The aim is to investigate expression, subunit composition and potential functions of nAChRs in B lymphocytes. Methods: immunoenzyme techniques, flow cytometry, NMR, hybridoma technologies, use of knockout and chimera animals. The presence of two nAChR subtypes in normal and transformed B-lymphocytes is demonstrated. It is established that they regulate these cells development and activation in the course of immune response. The data obtained help to explain the molecular basis of nicotine suppressive role in the antibody immune response and the increased incidence of autoimmune disorders found in tobacco smokers. Field of application: scientific and educational institutes of medical and biological profile.

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Files

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Disertazia.doc

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