Grinenko T. 3. Regulation of fibrinolysis by noncatalytic sites of plasminogen/plasmin molecule

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0507U000725

Thesis Registration Form

0507U000725.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

24-12-2007

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

3. The object of investigation: fibrinolytic system. The aim: to investigate molecular mechanism of fibrinolysis regulation. Method of study: preparational biochemistry, enzymology, immunology, spectrophotometry, electrophoresis. It was determined functional role of definite domaines noncatalytic sites of plasminogen/ plasmin on different stage of fibrinolytic process. It was declared, that the fibrin hydrolysis rate was determined by sequence of interactions between enzyme and substrate. Mechanism of fibrin clot hydrolysis rate regulation was proposed. Quantitative method to determine of fibrinolytic system general proteines in blood plasma was developed. Field of application: scientific and educational institutes of medical and biological type.

Read more

Files

avtoreferat_Grinenko.doc

disertaciya_Grinenko.doc

disertaciya_Grinenko.doc

Similar theses

0524U000046

Oksana V. Melnyk

Peculiarities of free-radical, immune, Ca2+- and NO-dependent regulatory systems of cells and their relationship with the microbiome under conditions of development of male infertility and concomitant autoimmune pathology

0422U100167

Lylyk Mariia Petrivna

Protective action of alpha ketoglutarate in Drosophila melanogaster for exposure to xenobiotics

0422U100159

Semaniuk Uliana Vasylivna

Regulation of physiological and biochemical traits of Drosophila melanogaster by diet and insulin-like peptides

0422U100023

Kotliar Iryna Petrivna

Biochemical mechanisms of anti-inflammatory action of pyrrole derivatives in ulcerative colitis

0521U102076

Danylovych Hanna Victorivna

Biosynthesis and regulatory role of nitric oxide in smooth muscle mitochondria