Vishchur O. Biochemical features of forming and regulation of immune response in calves' and piglets' organism in early age

The dissertation is devoted to the integrated studies of cellular and humoral immunity, immune reactivity, activity of enzymatic and nonenzymatic links of antioxidant defense system, some aspects of lipid and protein metabolism in the organism of calves and pigs in early age after vaccination, weaning of piglets from sows, and under the influence of immune tropic preparations ("Thymogen", "Levamysol", "Аntoxan", "Іmmucor", "Lipogen") on the above-mentioned indices. The stimulating influence of immune-response modulating preparations "Thymogen" and "Levamysol" on forming immune biological reactivity, activity of nonspecific defensive factors and peroxide lipid oxidation intensity in calves' and pigs'organism after vaccination was established. The compound and production technology of immune-response modulating preparation with antioxidant effect - "Antoxan" was elaborated. Corrective effect during strengthening of peroxide processes and forming full-value immune response was determined. The stimulatinginfluence of elaborated preparation "Immucor", on immune and antioxidant system functions, in the organism of calves was established. High prophylactic efficiency of complex liposome preparation "Lipogen" for reducind stress of piglets at weaning and for calves' resistance increase in early age was proved. The obtained results expand modern scientific conceptions concerning biochemical particular qualities of immune system (of calves and piglets in early age) forming and its correction with new complex immune modulating preparations at immune deficiency disorders, influence of vaccination, weaning of piglets from sows.