Yevdokimova N. The role of transforming growth factor beta1 in the regulation of structural-functional state of extracellular matrix in diabetes mellitus

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0509U000432

Thesis Registration Form

0509U000432.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

30-06-2009

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

Object:extracellular matrix of mesangial, endothelial cells and dermal fibroblasts. Aim: to investigate the role of TGFbeta1 activation in extracellular matrix alterations in diabetes mellitus. Methods: cell culture, biochemical, molecular biology. It was found that the increase of glucose level in mesangial, endothelial cells and dermal fibroblasts stimulates the accumulation of main extracellular matrix components, but mechanisms of the development of indicated alterations are different for each cell type. A key role of TGFbeta1activation in mesangial matrix derangement provides a background for new methods of diabetic nephropathy therapy.

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АВТОРЕФЕРАТ.doc

ТЕКСТ ДИСЕРТАЦІЇ.doc

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